Table 1. Pharmacologically and clinically relevant variants in which WETH had statistically significant allele frequency differences with at least three of the four other HapMap African populations.

				WETH Frq	MKK		ASW		LWK		YRI			Predicted function
SNP	Chr: pos	A1	A2		Frq	P	Frq	P	Frq	P	Frq	P	Gene		Drugs	Diseases	Effect
rs2242046*	15:38298203	A	G	0.46	0.23	7.54×10−3	0.10	1.17×10−5	0.06	1.19×10−6	0.00	9.42×10−12	SLC28A1	Missense	Gemcitabine	NSCC	Dose-related toxicity
rs7294**	16:31102321	A	G	0.20	0.52	1.93×10−3	0.53	9.40×10−4	0.45	0.02	0.59	1.30×10−5	VKORC1	3′UTR	Warfarin, Acenocoumarol, Coumarin	Arteriosclerosis, Heart diseases, Myocardial infarction, Peripheral vascular diseases, Pulmonary embolism, Stroke, Thromboembolism	Dose-related toxicity
rs2108622	19:15990431	T	C	0.37	0.21	ns	0.09	2.01×10−3	0.11	1.28×10−2	0.05	2.31×10−5	CYP4F2	Missense	Warfarin, Acenocoumarol, Phenprocoumon, Fluindione	Arteriosclerosis, Heart diseases, Myocardial infarction, Peripheral vascular diseases, Pulmonary embolism, Stroke, Thromboembolism	Dose-related toxicity
rs3764006**	12:21054369	G	A	0.33	0.48	ns	0.63	7.94×10−3	0.73	4.58×10−6	0.83	6.23×10−10	SLCO1B3	Synonymous	Rosuvastatin	Dyslipidemia	Clearance
rs20455	6:39325078	A	G	0.55	0.47	ns	0.24	4.12×10−3	0.22	1.20×10−3	0.10	8.25×10−9	KIF6	Missense	Pravastatin	Myocardial infarction	Efficacy
rs1799929*	8:18257994	T	C	0.62	0.45	ns	0.26	9.73×10−5	0.33	1.48×10−2	0.20	1.56×10−6	NAT2	Synonymous	Isoniazid, Pyrazinamide, Rifampin, Sulfamethoxazole, Trimethoprim	Tuberculosis	Doserelated toxicity
rs533486*	7:99440694	T	C	0.38	0.39	ns	0.11	6.96×10−3	0.09	1.05×10−3	0.04	3.02×10−6	CYP3A43	Intronic	Doceta×el	Neoplasms	Drug clearance
rs7483*	1:110279701	T	C	0.36	0.10	9.64×10−3	0.10	9.64×10−3	0.15	ns	0.03	3.28×10−6	GSTM3	Missense	Cisplatin, Cyclophosphamide	Neoplasms	Efficacy and toxicity
rs1495741*	8:18272881	A	G	0.87	0.82	NS	0.64	0.002	0.67	0.001	0.55	0.0005	NAT2	Downstream	Isoniazid, Sulfamethoxazole	Tuberculosis	Dose-related toxicity
rs437943	4:35372098	T	C	0.50	0.36	ns	0.22	2.66×10−2	0.13	1.42×10−5	0.17	5.85×10−4	ARAP2	Flanking 3′UTR	TNF-alpha inhibitors	Rheumatoid arthritis	Efficacy

Abbreviations: Chr, Chromosome; Pos, Base-pair physical position (hg19); A1, Allele 1; A2, Allele 2; Frq, frequency of A1; WETH, Wolaita from Wolaita zone, Ethiopia; ASW, African ancestry in Southwest USA; LWK, Luhya in Webuye, Kenya; MKK, Maasai in Kinyawa, Kenya; YRI, Yoruba in Ibadan, Nigeria; P, Bonferroni corrected P-value (nominal P × 443); ns, not significant after Bonferroni correction; NSSC, non-small cell cancer.

^*Also significant difference with CHB, CHD and JPT.

^**Also significant difference with GIH.