Table 1.
Demographic data
| Patients with schizophrenia (N=40) |
Healthy participants (N=40) |
|
|---|---|---|
| Male/female, no | 3 | 2 7/11 |
| Age, yr † | 26.8 (5.8) | 28.0 (7.7) |
| Age, yr range | 20-41 | 18-45 |
| Height, cm † | 179.3 (9.2) | 182.5 (9.0) |
| Height, yr range | 163-198 | 167-204 |
| Weight (kg) † | 76.3 (13.3) | 74.3 (9.1) |
| Weight, kg range | 55-110 | 57-92 |
| Handedness – right /left /ambidexter, no | 37/3/0 | 35/5/0 |
| Level of education, yr † | 10.4 (2.5)* | 13.8 (2.2) |
| Parental level of education, yr † | 13.6 (2.7) | 13.6 (3.2) |
| Age at first symptoms, yr † | 24.7 (5.6) | |
| Age at first symptoms yr range | 16.9-38.4 | |
| Duration of illness, mean (sd), months | 25.1 (17.4) | |
| Medication at time of the scan ‡¶ | ||
| Typical antipsychotics, no | 4 | |
| – median (range) Haldol eq. | 3.5 (4.7) | |
| Atypical antipsychotics, no | 29 | |
| – median (range) Haldol eq. | 7.1 (12) | |
| No medication at time of scan, no | 0 | |
| Cumulative medication†§ | ||
| Typical antipsychotics no | 1 | |
| – mean | 106.5 | |
| Atypical antipsychotics no | 22 | |
| – mean | 6208.4 (6830.9) | |
| Typical+Atypical antipsychotics no | 13 | |
| – mean | 10956.2 (9640.3) | |
| PANSS positive symptoms | 15.7 (5.6) | |
| PANSS negative symptoms | 15.6 (5.7) | |
| PANSS general symptoms | 31.0 (7.2) | |
| PANSS total score | 62.3 (15.8) | |
| CAN total score | 14.4 (7.9) |
p<0.01
values are mean ± SD
in 7 patients medication information was unavailable
haloperidol, broomperidol, pipamperon, thioridazine, flufenazine, perfenazine, zuclopentixol, penfluridol, pimozide, fluspirilen, largactil and flufenazine were considered typical antipsychotic drugs; clozapine, risperidone, olanzapine, and sertindole were considered atypical antipsychotic drugs.
in 4 patients cumulative medication use was unavailable.