Table 4.
ECAP and tremor recording conditions and outcomes across subjects. Log10(tremor) was quantified in the DBS off condition as the mean ± standard deviation (SD) across all trials in the tested block, and the change in tremor from the preceeding baseline with 10 or 130 Hz DBS at the clinical voltage (or highest voltage tested if less than the clinical voltage), averaged across cathodic- and anodic-phase first polarities. For change in tremor, negative values indicate tremor reduction and positive values indicate tremor exacerbation with DBS.
| Subject | Recording Condition | ECAP Recording Fidelity | Mean±SD log10(tremor), DBS Off | Change in tremor | |
|---|---|---|---|---|---|
| 130 Hz DBS | 10 Hz DBS | ||||
| EP12A | Chronic | ECAP present with large artifact | 1.15±0.40 | −0.94 | 0.11 |
| EP12B | Chronic | ECAP present with large artifact | −1.55±0.16 | −0.47 | 0.21 |
| EP12C | Chronic | Large artifact | N/A: accelerometer signal contaminated by noise | ||
| EP12D | Chronic | ECAP present | −0.84±0.34 | −0.20 | −0.13 |
| EP12E | Chronic | No amplifier blanking | 0.58+/−1.15 | −1.28 | 2.07 |
| EP13A | Chronic | Large artifact | −1.55+/−0.31 | 0.32 | −0.15 |
| EP13B | Acute | ECAP present | −1.10+/−1.37 | −1.21 | 0.55 |
| EP13C | Acute | Poor fidelity due to bad connection | 0.86+/−0.12 | 0.14 | 0.14 |
| EP13E | Acute | Poor fidelity due to bad connection | −1.60+/−0.13 | −0.29 | 0.19 |
| EP13F | Chronic | Large artifact | 1.13+/−1.00 | −1.22 | −1.43 |
| EP13G | Acute | ECAP present with minimal artifact | −0.11+/−1.01 | −2.33 | 0.11 |
| EP13H | Acute | Poor fidelity due to bad connection | −1.81+/−0.13 | −0.49 | 0.67 |
| EP13I | Acute | ECAP present | −2.25+/−0.14 | 0.15 | 0.27 |
| EP13J | Acute | ECAP present with inimal artifact | 1.96+/−0.27 | −1.07 | −0.12 |
| EP13K | Chronic | Large artifact | 2.78+/−0.24 | −3.46 | −0.06 |
| EP13L | Chronic | ECAP present with minimal artifact | −1.35+/−0.18 | −0.24 | 0.05 |
| EP13N | Acute | ECAP present | −1.08+/−0.46 | −0.65 | 2.45 |