Table 3.
| Table 3a. IgG2 Antibody levels across age groups in an area of stable malaria transmission
| |||||
|---|---|---|---|---|---|
| Antigen | Median level (AU) (min, max) for age groups:
|
P value a (trend for age) | |||
| 2–5 yr (n=14) | 6–15 yr (n=30) | 16–40 yr (n=44) | >40 yr (n=28) | ||
| CSP | 0.62 (0.00,0.95) | 0.80 (0.00,2.73) | 1.29 (0.00,16.88) | 3.46 (0.28,100.66) | <0.001 |
| LSA-1 | 0.37 (0.00,70.35) | 0.76 (0.04,100.16) | 5.66 (0.05,170.57) | 1.97 (0.09,120.90) | 0.004 |
| TRAP | 0.27 (0.00,0.51) | 0.49 (0.03,35.84) | 0.59 (0.01,21.14) | 0.83 (0.03,9.64) | 0.001 |
| AMA-1 | 0.07 (0.00,0.85) | 0.08 (0.01,0.37) | 0.13 (0.00,2.62) | 0.18 (0.03,9.72) | <0.001 |
| EBA-175 | 0.49 (0.00,2.93) | 0.76 (0.26,14.50) | 1.02 (0.00,33.59) | 0.77 (0.09,4.67) | 0.082 |
| MSP-1 | 0.16 (0.00,0.54) | 0.32 (0.00,1.39) | 0.85 (0.00,2.69) | 0.77 (0.17,2.95) | <0.001 |
| Table 3b. IgG2 Antibody levels across age groups in an area of unstable malaria transmission
| |||||
|---|---|---|---|---|---|
| Antigen | Median level (AU) (min, max) for age groupsb:
|
P value a (trend for age) | |||
| 2–5 yr (n=19) | 6–15 yr (n=12) | 16–40 yr (n=37) | >40 yr (n=28) | ||
| CSP | 0.00 (0.00,1.36)* | 0.00 (0.00,0.54)* | 0.38 (0.00,1.04)* | 0.64 (0.13,3.20)* | <0.001 |
| LSA-1 | 0.16 (0.03,2.14) | 0.10 (0.00,2.46)* | 0.29 (0.00,10.49)* | 1.10 (0.00,28.90) | <0.001 |
| TRAP | 0.14 (0.00,11.62) | 0.06 (0.00,3.48)* | 0.16 (0.00,1.07)* | 0.31 (0.06,3.68)* | 0.113 |
| AMA-1 | 0.08 (0.00,0.50) | 0.05 (0.00,1.43) | 0.06 (0.00,0.82)* | 0.09 (0.00,0.71)* | 0.199 |
| EBA-175 | 0.28 (0.00,1.01)* | 0.17 (0.00,0.85)* | 0.43 (0.00,3.49)* | 1.77 (0.02,10.84) | <0.001 |
| MSP-1 | 0.31 (0.00,1.27) | 0.07 (0.00,0.77)* | 0.21 (0.00,1.01)* | 0.39 (0.00,1.54)* | 0.136 |
a
Non-parametric test for trend across ordered groups (see Materials and Methods)
b
Asterisk (*) indicates significantly different from antibody level for same antigen and age group in stable transmission area (P<0.05 by Wilcoxon rank-sum test).