Table 4.

Table 4a. IgG3 Antibody levels across age groups in an area of stable malaria transmission
Antigen	Median level (AU) (min, max) for age groups:				P value ^a (trend for age)
Antigen	2–5 yr (n=14)	6–15 yr (n=30)	16–40 yr (n=44)	>40 yr (n=28)	P value ^a (trend for age)
CSP	2.74 (0.53,56.98)	5.19 (0.62,81.76)	15.07 (1.79,231.85)	23.6 (3.56,223.93)	<0.001
LSA-1	10.51 (0.41,125.84)	26.06 (0.31,192.88)	49.27 (0.15,179.06)	35.87 (2.60,152.15)	0.075
TRAP	7.29 (0.79,61.96)	13.18 (0.85,103.07)	53.32 (4.73,280.59)	66.22 (12.71,241.89)	<0.001
AMA-1	1.86 (0.05,37.37)	2.55 (0.08,19.99)	3.66 (0.88,39.53)	4.38 (1.04,12.61)	0.002
EBA-175	4.02 (0.00,116.98)	8.27 (0.00,113.69)	5.35 (0.00,171.31)	3.61 (0.00,34.94)	0.117
MSP-1	4.67 (1.19,27.19)	5.05 (0.59,33.77)	14.86 (1.13,93.56)	14.39 (2.11,80.54)	<0.001

Table 4b. IgG3 Antibody levels across age groups in an area of unstable malaria transmission
Antigen	Median level (AU) (min, max) for age groups^b:				P value ^a (trend for age)
Antigen	2–5 yr (n=19)	6–15 yr (n=12)	16–40 yr (n=37)	>40 yr (n=28)	P value ^a (trend for age)
CSP	1.29 (0.21,8.80)*	1.07 (0.29,2.29)*	0.58 (0.13,8.17)*	1.13 (0.15,5.30)*	0.214
LSA-1	0.59 (0.19,15.52)*	0.45 (0.00,0.72)*	0.99 (0.00,179.06)*	1.87 (0.03,185.69)*	<0.001
TRAP	0.66 (0.00,54.17)*	0.59 (0.15,3.39)*	0.78 (0.05,88.84)*	2.10 (0.34,125.62)*	0.006
AMA-1	0.10 (0.00,0.26)*	0.09 (0.00,0.25)*	0.82 (0.07,10.47)*	0.70 (0.27,6.86)*	<0.001
EBA-175	0.06 (0.00,2.73)*	0.05 (0.00,0.95)*	1.35 (0.00,76.39)*	2.50 (0.32,79.91)	<0.001
MSP-1	1.15 (0.36,2.30)*	1.30 (0.56,1.99)*	1.36 (0.24,29.71)*	1.35 (0.62,56.32)*	0.132

Non-parametric test for trend across ordered groups (see Materials and Methods)

Asterisk (*) indicates significantly different from antibody level for same antigen and age group in stable transmission area (P<0.05 by Wilcoxon rank-sum test).