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. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Nov 26;25(2):276–279. doi: 10.1016/j.bmcl.2014.11.053

Table 1.

cLogP, solubility and stability of selected compounds.

Structure EHI# cLogP Solubility (μM)b Stability (%)c
Human liver mic. Chicken liver mic.
NADPH − + − +
graphic file with name nihms645548t1.jpg AUDA 5.98
−1.14a 		37.5–50 98 ± 14 69 ± 5 106 ± 7 70 ± 1
graphic file with name nihms645548t2.jpg 1138 4.97 10–12.5 98 ± 3 57 ± 21 69 ± 29 2.1 ± 0.5
graphic file with name nihms645548t3.jpg 1471 4.84
0.62a 		> 100 97 ± 8 69 ± 2 77 ± 2 60 ± 4
graphic file with name nihms645548t4.jpg 1749 2.90 75–100 1.2 ± 0.5 2.7 ± 0.8 105 ± 9 94 ± 4
graphic file with name nihms645548t5.jpg 2119 3.84 > 100 91 ± 6 53 ± 2 73 ± 1 24 ± 2
graphic file with name nihms645548t6.jpg 2225 3.88 50–75 101 ± 4 94 ± 2 96 ± 5 96 ± 3
graphic file with name nihms645548t7.jpg 2228 4.08 10–12.5 101 ± 5 5.4 ± 0.1 119 ± 15 89 ± 15
a

Base form.

b

In sodium phosphate buffer (0.1 M pH 7.4)

c

Percent of compound (1 μM) remaining after 30 minutes incubation with human or chicken liver microsomes (1 mg/mL) at 37°C with or without NADPH generating system. Results are average ± standard deviation (n = 3).