Table 1.
In Vivo Antimalarial Efficacy using a Single Oral Dose of Trioxane Dimer (6 mg/kg) Combined with Mefloquine Hydrochloride (18 mg/kg) in P. berghei-Infected Mice.
| trioxane | Survival after infection (days)a | avg survival (days) | % Parasitemia Suppressionb |
|---|---|---|---|
| 4 | 29, 18, 30, 27 | 26 | >99.9 |
| 5a | 29, 18, 30, 20 | 24.3 | >99.9 |
| 5b | 24, 23, 30, 27 | 26 | >99.9 |
| 5c | 13, 30, 30, 30 | 25.8 | >99.9 |
| 5d | 29, 25, 30, 30 | 28.5 | >99.9 |
| 5e | 30, 13, 30, 30 | 25.8 | >99.9 |
| 5f | 30, 21, 13, 30 | 23.5 | >99.9 |
| 5g | 29, 27, 30, 30 | 29 | >99.9 |
| 5h | 30, 30, 30, 30 | 30 | >99.9 |
| 5i | 30, 30, 30, 30 | 30 | >99.9 |
| controls: | |||
| infected mice (no drug) | 6, 6, 6, 7 | 6.3 | 0%c |
| artemether (2) plus mefloquine | 20, 30, 13, 20 | 20.8 | >99.9 |
| mefloquine alone | 13, 29, 18, 23 | 20.8 | >99.9 |
a
Bold entries indicate best results.
b
Denotes determination on day 3 after infection.
c
An average of 10.3% parasitemia was determined on day 3 after infection.