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Proposed outline mechanism of electrophile-promoted Zn(II) ejection from p300 (a); Zn(II) binding sites in the CH1 domain of p300 (b) are structurally similar to those found in other proteins including the catalytic domain of KDM4A (c). PDB: p300: IL3E and KDM4A: 2PXJ respectively [14,52].
