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. 2014 Nov 19;136(48):16792–16799. doi: 10.1021/ja5064857

Figure 4.

Figure 4

Sequestration analysis of atom replaced mimetics. (a) 1H,15N-HSQC overlays depicting the holo-actACP (2, red) and the crypto-C8-actACP (4a, pink), crypto-C8-actACP (4b, orange) bearing 11 and 20, respectively. (b) CSP plots obtained from the spectra shown in panel (a). (c) 1H,15N-HSQC traces depicting overlays of the holo-actACP (2, red), crypto-C14-actACP (5b, green) bearing heptaketide mimetic 22 and crypto-C16-actACP (6b, blue) bearing the octaketide mimetic 23. (d) CSP plots obtained from the spectra shown in panel (c). The docked actACP structure with these probes can be found in Figure S34.