Scheme 2. Posttranslational Maturation of His6P-HalA2 and ProcA2.8 Catalyzed by HalM2 and ProcM, Respectively.
The Ser and Thr residues to be dehydrated are yellow, and the Cys residues involved in cyclization are pink. Amino acid residues are numbered here and throughout the text according to their position relative to the start of the core peptide. The underlined portion of the leader sequence for each peptide is derived from the vector used for expression of the peptide and is not part of the native amino acid sequence. Dhb, dehydrobutyrine; Abu, 1-α-aminobutric acid.