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Radiosensitivity of PC3 cells treated with PX-478. (a) PC3 cells were treated with PX-478 under normoxia for 24 hr, irradiated under normoxia and plated after 1 hr. (b) PC3 cells were treated with PX-478 under normoxic condition for 20 hr, subjected to 1-hr hypoxia, irradiated under hypoxic condition and plated after 1 hr. Each data point represents Av ± SEM of 3 separate experiments. Survival curve with 30 μM PX-478 is from a single experiment.
