Table 2.
The laboratory characteristics of the study subjects (n = 40) before and after one week of oral creatine supplementation
| Characteristics | Before Creatine | After Creatine | pvalue |
|---|---|---|---|
| Homocysteine (μmol/L) | 10.5 (8.2-13.0) | 10.1 (8.8-12.3) | 0.4434 |
| Uric acid (mg/dL) | 4.9 ± 0.2 | 4.3 ± 0.2 | 0.0004 |
| Urea (mg/dL) | 34.5 ± 1.5 | 35.7 ± 2.0 | 0.2482 |
| Creatinine (mg/dL) | 0.92 ± 0.02 | 1.03 ± 0.03 | 0.0001 |
| CK-MB (U/L) | 18.0 (11.5-25.0) | 18.0 (13.0-27.0) | 0.7601 |
| CK-MM (U/L) | 253 (146-567) | 344 (128-653) | 0.0296 |
| Troponin (ng/mL) | 0.0017 ± 0.0006 | 0.0029 ± 0.0010 | 0.4082 |
| AST (U/L) | 33.6 ± 1.8 | 36.4 ± 2.3 | 0.1718 |
| ALT (U/L) | 31.1 ± 2.6 | 30.1 ± 2.1 | 0.4380 |
| Lactate dehydrogenase (U/L) | 200.0 (159.5-335.0) | 215.0 (166.0-315.5) | 0.5694 |
| Alkaline phosphatase (U/L) | 59.0 (53.0-76.0) | 58.0 (49.5-77.0) | 0.5875 |
| Fibrinogen (mg/dL) | 282 (256-306) | 254 (227-284) | 0.0177 |
| Triglycerides (mg/dL) | 67.0 (56.6-91.5) | 65.0 (51.5-91.0) | 0.7420 |
| Total cholesterol (mg/dL) | 174.0 (143.5-204.0) | 174.0 (140.0-197.5) | 0.0486 |
| HDL-C (mg/dL) | 43.3 ± 1.8 | 44.6 ± 2.1 | 0.1999 |
| LDL-C (mg/dL) | 115.0 (88.0-142.5) | 103 (81.0-130.0) | 0.0027 |
| Fasting glucose (mg/dL) | 86.5 ± 1.0 | 86.0 ± 1.4 | 0.7298 |
| Glycated hemoglobin (%) | 5.3 ± 0.07 | 5.3 ± 0.09 | 0.7980 |
| hs-CRP (mg/dL) | 0.07 (0.04-0.19) | 0.07 (0.04-0.18) | 0.7645 |
| Total protein (g/dL) | 7.3 ± 0.06 | 7.2 ± 0.07 | 0.0282 |
| Albumin (g/dL) | 4.2 ± 0x.04 | 4.2 ± 0.04 | 0.6203 |
| Globulins (g/dL) | 3.1 ± 0.06 | 3.0 ± 0.08 | 0.0588 |
| TSH (μUI/mL) | 2.1 (1.4-3.0) | 2.1 (1.5-2.7) | 0.4788 |
| T3 (ng/dL) | 1.08 ± 0.03 | 1.02 ± 0.03 | 0.0074 |
| T4 (ng/dL) | 1.08 ± 0.02 | 1.1 ± 0.02 | 0.0003 |
The results are presented as the mean ± SEM. For values that did not follow a Gaussian distribution, the medians (25th - 75th percentile) are presented (Shapiro-Wilk normality test).
HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol, CK-MB: Creatine Kinase-MB; CK-MM: Creatine Kinase-MM; AST: Aspartate transaminase; ALT: Alanine transaminase; hs-CRP: high-sensitivity C-reactive protein; TSH: thyroid stimulating hormone; T3: triiodothyronine; T4: thyroxine.
p values were estimated using two-tailed unpaired Student’s t tests or Wilcoxon matched-pairs tests, as appropriate.
Bold values denote significant differences.