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. Author manuscript; available in PMC: 2014 Dec 28.
Published in final edited form as: Horm Metab Res. 2008 Sep 25;41(1):35–39. doi: 10.1055/s-0028-1087188

Figure 1.

Figure 1

The effects of eplerenone (open circles) and spironolactone (solid circles) on MR transactivation by aldosterone (1 nM) in HEK-293T/17 cells. Expression plasmids for human MR and -galactosidase were transfected into HEK-293T/17 cells together with a mineralocorticoid responsive MMTV-luciferase reporter plasmid. Luciferase and -galactosidase enzyme activities were measured in cell lysates after incubation with aldosterone (1 nM) for 6 h. Basal luciferase activity was 19 % of that seen with aldosterone treatment. Mean values are based on data from three independent experiments.