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. Author manuscript; available in PMC: 2014 Dec 28.
Published in final edited form as: Circ Heart Fail. 2014 May 8;7(4):663–672. doi: 10.1161/CIRCHEARTFAILURE.114.001266

Figure 2.

Figure 2

Muscle A-kinase anchoring protein β (mAKAPβ) is important for catecholamine and exercise-induced hypertrophy. A–F, mAKAP CKO (mAKAPfl/fl;MCM+tamoxifen [Tam]) and control MCM+Tam and mAKAPfl/fl;MCM mice were infused for 2 weeks with saline±isoproterenol (Iso). A, M-mode echocardiography for left ventricular posterior wall thickness in diastole (LVPW;d); cf Table III in the Data Supplement. B, Biventricular weight indexed to body weight; cf Table IV in the Data Supplement. C and D, Myocyte cross section area was determined by wheat germ agglutinin staining. Bar=50 μm (n=3–6). E and F, Isolated adult myocytes were measured for width and length for the mAKAP CKO and MCM+Tam cohorts. n=3 to 7 mice; >100 myocytes assayed per mouse. G, mAKAP CKO and MCM+Tam mice were forced to swim or rested for 5 weeks. Biventricular weight indexed to body weight is shown; cf Table VI in the Data Supplement. *Vs saline-infused or resting mice of same genotype; †vs MCM+Tam; ‡vs mAKAPfl/fl;MCM.