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. Author manuscript; available in PMC: 2014 Dec 28.
Published in final edited form as: Circ Heart Fail. 2014 May 8;7(4):663–672. doi: 10.1161/CIRCHEARTFAILURE.114.001266

Figure 7.

Figure 7

Model for muscle A-kinase anchoring protein β (mAKAPβ) signalosome-regulated remodeling. mAKAPβ anchored by nesprin-1α at the nuclear envelope coordinates the activity of transcription factors that transiently dock the scaffold. CaNAβ dephosphorylates and activates nuclear factor of activated T-cell (NFATc) and myocyte-enhancer factor (MEF) 2. Mitogen-activated protein kinase/ ERK kinase 5 (MEK5) and extracellular signal–regulated kinase (ERK) 5 activate ribosomal S6 kinase (RSK). Protein kinase D (PKD) phosphorylates and inactivates histone deacetylase (HDAC) 4, derepressing hypertrophic gene expression.