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. 2014 Jul 29;9(1):44–57. doi: 10.1016/j.molonc.2014.07.013

Figure 2.

Figure 2

Reverse of T cell recruitment by blocking the CXCL9 with neutralizing antibody. A. Q‐PCR screening of a panel of cytokine factors that could be responsible for PCa cell promoted T cell migration. Compared to the RWPE‐1 cells, C4‐2 cells can express more CXCL9 (*P < 0.05). B. Higher expression of CXCL9 mRNA was confirmed in LNCaP and CWR22RV1 (22RV1) cell lines using q‐PCR (*P < 0.05). C&D. The PCa cell‐promoted HH and Molt‐3 migrations were partly blocked after adding CXCL9 neutralizing antibody (4 μg/ml) into PCa CM in bottom chambers (*P < 0.05).