Table 3.
T2D and risk of incident AF, stratified by selected baseline characteristics
| Characteristic | No baseline T2D (n=33783) | Baseline T2D(n=937) | P Value* |
|---|---|---|---|
| Age ≥ 65 y | 0.01 | ||
| Yes (n = 3430) | |||
| Events/participants | 250/3294 | 8/136 | |
| HR (95% CI) | 1 [Reference] | 0.85 (0.42 – 1.74) | |
| No (n = 31290) | |||
| Events/participants | 773/30489 | 48/801 | |
| HR (95% CI) | 1 [Reference] | 1.54 (1.13 – 2.11) | |
| Body mass index | 0.10 | ||
| < 25 kg/m2 (n = 17720) | |||
| Events/participants | 431/17546 | 3/174 | |
| HR (95% CI) | 1 [Reference] | 0.53 (0.17 – 1.66) | |
| 25 – 30 kg/m2 (n = 10707) | |||
| Events/participants | 331/10418 | 16/289 | |
| HR (95% CI) | 1 [Reference] | 1.19 (0.68 – 2.09) | |
| > 30 kg/m2 (n = 6260) | |||
| Events/participants | 260/5791 | 37/469 | |
| HR (95% CI) | 1 [Reference] | 1.73 (1.21 – 2.48) | |
| Hypertension | 0.70 | ||
| Yes (n = 9175) | |||
| Events/participants | 430/8586 | 44/589 | |
| HR (95% CI) | 1 [Reference] | 1.43 (1.03 – 2.00) | |
| No (n = 25545) | |||
| Events/participants | 593/25197 | 12/348 | |
| HR (95% CI) | 1 [Reference] | 1.22 (0.69 – 2.17) | |
| Hypercholesterolemia | 0.82 | ||
| Yes (n = 10484) | |||
| Events/participants | 359/10041 | 27/443 | |
| HR (95% CI) | 1 [Reference] | 1.37 (0.91 – 2.07) | |
| No (n = 24236) | |||
| Events/participants | 664/23742 | 29/494 | |
| HR (95% CI) | 1 [Reference] | 1.35 (0.91 – 2.02) | |
| Current Smoking | 0.98 | ||
| Yes (n = 4306) | |||
| Events/participants | 92/4179 | 5/127 | |
| HR (95% CI) | 1 [Reference] | 1.48 (0.57 – 3.84) | |
| No (n = 30388) | |||
| Events/participants | 929/29578 | 51/810 | |
| HR (95% CI) | 1 [Reference] | 1.35 (1.00 – 1.83) | |
T2D=Type 2 diabetes
*
P value for interaction based on a likelihood ratio test with and without interaction terms in the models
All hazard ratios were adjusted for age, smoking, exercise, alcohol consumption, education, race/ethnicity, hypercholesterolemia, hypertension, body mass index, and adult height