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Biochemical or symptomatic deterioration in patients with HBeAg-positive CHB according to serum HBV DNA and ALT levels. The patients were categorized into the following four groups: group 1 (n=24), low HBV DNA (<5.1×107 IU/mL) and low ALT (<5×ULN); group 2 (n=15), low HBV DNA and high ALT (≥5×ULN); group 3 (n=36), high HBV DNA (≥5.1×107 IU/mL) and low ALT; and group 4 (n=15), high HBV DNA and high ALT.
