Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Improvement in fine wrinkles
Systematic review	117 people with moderate skin photodamage Data from 1 RCT	Proportion of people with improved fine facial wrinkles (physician-assessed using a 6-point scale: 0 = none to 5 = very severe) 24 weeks 27/59 (46%) with tazarotene 0.01% (applied once-daily for 24 weeks) 32/58 (55%) with tretinoin 0.05% (applied once-daily for 24 weeks)	RR 1.21 95% CI 0.84 to 1.73		Not significant
Systematic review	117 people with moderate skin photodamage Data from 1 RCT	Proportion of people with improved fine facial wrinkles (physician-assessed using a 6-point scale: 0 = none to 5 = very severe) 24 weeks 20/58 (34%) with tazarotene 0.025% (applied once-daily for 24 weeks) 32/58 (55%) with tretinoin 0.05% (applied once-daily for 24 weeks)	RR 1.60 95% CI 1.05 to 2.44	Small effect size	tretinoin 0.05%
Systematic review	117 people with moderate skin photodamage Data from 1 RCT	Proportion of people with improved fine facial wrinkles (physician-assessed using a 6-point scale: 0 = none to 5 = very severe) 24 weeks 28/58 (48%) with tazarotene 0.05% (applied once-daily for 24 weeks) 32/58 (55%) with tretinoin 0.05% (applied once-daily for 24 weeks)	RR 1.14 95% CI 0.80 to 1.63		Not significant
Systematic review	117 people with moderate skin photodamage Data from 1 RCT	Proportion of people with improved fine facial wrinkles (physician-assessed using a 6-point scale: 0 = none to 5 = very severe) 24 weeks 32/58 (55%) with tazarotene 0.1% (applied once-daily for 24 weeks) 32/58 (55%) with tretinoin 0.05% (applied once-daily for 24 weeks)	RR 1.00 95% CI 0.72 to 1.39		Not significant
RCT	173 people, mean age 55 years, with Fitzpatrick skin types I–IV	Proportion of people with improved fine wrinkling by at least 1 grade on a 5-point scale 24 weeks 70/88 (80%) with tazarotene 0.1% (applied once-daily in the evening for 24 weeks) 53/85 (62%) with tretinoin 0.05% (applied once-daily in the evening for 24 weeks)	P <0.01	Effect size not calculated	tazarotene 0.1%
Improvement in coarse wrinkles
RCT	173 people, mean age 55 years, with Fitzpatrick skin types I–IV	Proportion of people with improved coarse wrinkling by at least 1 grade on a 5-point scale 24 weeks 34/88 (39%) with tazarotene 0.1% (applied once-daily in the evening for 24 weeks) 29/85 (32%) with tretinoin 0.05% (applied once-daily in the evening for 24 weeks)	P <0.05	Effect size not calculated	tazarotene 0.1%