Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Improvement in fine wrinkles
RCT 3-armed trial	74 women In review	Physician-assessed improvement of fine facial wrinkling (measured on a 10-point scale: 0 = none and 9 = severe) 22 weeks 22% with lactic acid 8% (applied twice-daily) 15% with vehicle cream (applied twice-daily)	P <0.05	Effect size not calculated	lactic acid 8%
RCT 3-armed trial	74 women In review	Mean grade change of physician-assessed fine facial wrinkling (measured on a 10-point scale: 0 = none and 9 = severe) 22 weeks –1.04 with lactic acid 8% (applied twice-daily) –0.86 with vehicle cream (applied twice-daily)	P <0.05	Effect size not calculated	lactic acid 8%