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. 2015 Jan;145(1):47–60. doi: 10.1085/jgp.201411272

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© 2015 Yeh et al.

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Figure 8. — NO₃⁻ and VX-770 potentiate ΔNBD2- and G551D-CFTR in an independent manner. (A) Quantitative assessments of the effect of NO₃⁻ and VX-770 on ΔNBD2-CFTR’s activity. The current trace shown in the inset represents the standard protocol that allows us to calculate the ratios of mean current amplitudes for each treatment as labeled. A specific CFTR inhibitor, Inh-172, was applied at the end of each experiment to attain the baseline. These ratios were converted to ratios of P_o by correcting differences in single-channel amplitudes (see Materials and methods for detail). The bar chart summarizes these results. P_o(N), P_o in NO₃⁻ bath; P_o(C₎, P_o in Cl⁻ bath; P_o(V:N), P_o in NO₃⁻ bath with VX-770; P_o(V:C), P_o in Cl⁻ bath with VX-770. (B) Independent potentiation of G551D-CFTR by NO₃⁻ and VX-770. The current trace in the inset illustrates the results of G551D-CFTR channels under the same experimental protocol shown in A. Summary of the P_o ratios obtained as described above. The error bars represent the SEM of the mean.