Figure 4.

MiR-467a-kockdown suppresses thymic lymphoma growth in vivo. P-R/T/L cells were transiently transfected with miR-467a ASO or miR-NC ASO vector, while EL4 cells were stably transfected with the aforementioned vectors. Then these tumor cells were used in transplant experiments. (A) Tumor formation rate of treated EL4 cells. (B) Tumor formation rate of treated P-R/T/L cells, using untreated P-R/T/L cells as control. The data represent mean±SD of duple determinations. (C) In vivo anti-tumor effects of miR-467a ASO vector on EL4 cells. Tumor volumes were calculated in 40 days after inoculation. Left panel shows tumor growth curves. The data represent mean±SD of quadruplicate determinations. Right panel shows overall survival curves of mice bearing EL4 tumor according to miR-467a level (n=12, each group). * p < 0.05.