Figure 1.

Following injury pericytes in multiple organs, including kidney, liver and skin, can migrate from their usual perivascular location and transdifferentiate into matrix-secreting myofibroblasts. Potential therapeutic targets to inhibit this process are shown. TGFβ, transforming growth factor beta; PDGFRβ, platelet-derived growth factor receptor beta; VEGFR2, vascular endothelial growth factor receptor 2; PPARγ, peroxisome proliferator-activated receptor gamma; CTGF, connective tissue growth factor.