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. 2014 Oct 24;1(11):709–724. doi: 10.18632/oncoscience.91

Figure 7. Proposed model for a KLK5-miRNA-ECM network in breast cancer.

Figure 7

KLK5 regulates ECM and cell adhesion both directly through its proteolyitc activity, and through miRNA-mediated pathways. KLK5 overexpression results in up-regulation of a subset of miRNAs and down-regulation of another miRNA subset. miRNA under-expression can be mediated through affecting critical enzymes involved in miRNA biogenesis which in turn can be mediated through the up-regulation of a number of miRNAs that are known to target these enzymes. These pathways merge to have an amplified downstream impact on ECM regulation, breast cancer phenotype and metastatic potential.