Table 2. Differential expression of the predicted targets of the top dysregulated miRNAs in MDA-MB-231 cell lines with KLK5 reconstituted expression.

Up-regulated miRNA		Gene mRNA Target in Homo sapiens		Down-regulated miRNA		Gene mRNA Target in Homo sapiens
miRNA	Fold Change*	Symbol	mRNA Dysregulation**	miRNA	Fold Change*	Symbol	mRNA Dysregulation**
miR-183-5p	83.4	CX3CL1	−3.85	miR-935	−225.3	TNRC6B	1.48
		TUB	−2.13			DNMT3B	1.59
		RPS6KA3	−1.56			ARL3	1.65
miR-206	30.41	DNAL1	−2			HMGB1	1.77
		MPZL1	−1.89			MBNL2	1.82
		NMT2	−1.69	miR-519a-3p	−102.1	FMNL3	1.46
		SLC7A6	−1.59			TNRC6B	1.48
		HIGD1A	−1.54			C1orf63	1.53
		HSPD1	−1.47			GLS	1.61
		DLG4	−1.47			ZFHX4	1.64
		G3BP2	−1.47			SLC25A23	1.64
		POLA1	−1.45			ATM	1.75
		PLCG1	−1.45			SORL1	1.83
miR-181c-5p	25.59	CYP26B1	−2.13			LDLR	1.97
		TUB	−2.13			ZHX2	2.31
		DNAL1	−2			FILIP1L	3.69
		FGFR3	−1.89	miR-888-5p	−48.29	KIF1B	1.6
		RASSF2	−.185			DEPDC1B	1.68
		NMT2	−1.69			SORL1	1.83
		ZNF594	−1.67			ZHX2	2.31
		RPS6KA3	−1.56			KCTD12	2.36
		G3BP2	−1.47	miR-10b-5p	−20.12	TNRC6B	1.48
		POLA1	−1.45			RBMS3	1.81
miR-449b-5p	14.99	LMTK3	−3.57			SIX4	1.83
		SYNJ1	−1.75			STARD13	2.01
		NMT2	−1.69			NAV1	2.28
		SLC7A6	−1.59	miR-520d-3p	−17.312	MRPS25	1.44
		PLCG1	−1.45			FMNL3	1.46
		C16orf5	−1.43			TNRC6B	1.48
miR-1301	13.5	NBL1	−1.67			ARHGEF18	1.49
		G3BP2	−1.47			RAB22A	1.59
miR-335-5p	4.742424	NMT2	−1.69			GLS	1.61
						PDCD4	1.64
						ZFHX4	1.64
						FNDC3A	1.68
						SLC35E1	1.82
						MBNL2	1.82
				miR-1255b-5p	−14.962	NAV1	2.28
						FILIP1L	3.69
				miR-650	−12.622	TNRC6B	1.48
						ZFHX4	1.64
						TRAF1	1.69
						SORL1	1.83
						SCD	4.99
				miR-342-3p	−10.714	DLGAP4	1.59
						ZFHX4	1.64
						SORL1	1.83

^*Assessed by qRT-PCR screening

^**Assessed by Illumina Chip