Table 2. Significantly altered KEGG pathways in mammary gland upon 96h of 80kVp/0.1 Gy in comparison to the corresponding un-treated controls.
In this table, the pathway significance (%) is defined as the ratio of gene alterations that similarly affect a certain pathway (either up- or down-regulate) to the total number of altered genes in the pathway. “+” – the pathway is up-regulated; “-” – the pathway is down-regulated.
| Pathways | Pathway Significance, % (total number of genes) |
|---|---|
| Antigen processing and presentation | + 93.8% (16) |
| B cell receptor signaling | + 100% (13) |
| Cell adhesion molecules (CAM) | + N/S (20) |
| Chemokine signaling | + 100% (14) |
| Citrate cycle (TCA) | − 100% (8) |
| Cytosolic DNA-sensing pathway | + 100% (6) |
| ECM-receptor interaction | − 88.9% (9) |
| Fatty acid metabolism | − 100% (6) |
| Fc epsilon RI signaling | + 100% (10) |
| Fc gamma R-mediated phagocytosis | + 100% (11) |
| Glutathione metabolism | − 85.7% (7) |
| Graft-vs-host disease | + 100% (7) |
| Hematopoietic cell lineage | + N/S (9) |
| Intestinal immune network for IgA production | + 100% (6) |
| Leukocyte transendothelial migration | + 89.5% (19) |
| Lysosome | + N/S (13) |
| Natural killer cell mediated cytotoxicity | + 100% (18) |
| PPAR signaling | − 100% (10) |
| Primary immunodeficiency | + 100% (8) |
| Pyruvate metabolism | − 100% (7) |
| T cell receptor signaling | + 100% (15) |
| Tryptophan metabolism | − 83.3 % (6) |