Figure 9. Schematic model for edelfosine-induced cell death in U118 cells.

(upper) This is a schematic diagram that depicts the cell death mechanisms triggered during the edelfosine killing action in U118 glioblastoma cells, and highlights the involvement of RIPK1/RPK3-mediated necroptotosis in the process. (lower) When necroptosis is inhibited, the caspase-dependent apoptotic response is potentiated following edelfosine treatment. See the text for details.