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. 2014 Oct 15;1(10):634–648. doi: 10.18632/oncoscience.87

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© 2014 Van Bockstal et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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T47D cells were seeded onto CAF-derived matrices with or without decorin coating, and cell adhesion was measured by MTT (A) and SRB (B) assay after 24 hours. Results are presented from three wells per assay from two independent experiments. Values are mean percentage ± SD. CAFs that produced the matrices were treated either with vehicle control, bFGF, TGF-β1 or both cytokines. (C) When seeded on matrices derived from TGF-β1-treated CAFs, T47D cells adhered in an organized fashion along preformed ‘tracks’ in the matrices, whereas the control or bFGF treatment showed a rather random distribution of the cells, with formation of more and larger cellular islands. Scale bar: 200 μm.