Table 1. Frequency and intensity of expression of ANXA1, CAV-1, EphA2 and SRC kinase in melanoma samples as measured by immunohistochemistry.
| IHC Results | ANXA1 | CAV-1 | EphA2 | SRC kinase | Positive for 4 markers | SRC positive tumours with moderate/strong staining for ANXA1, CAV-1, and EphA2 |
|---|---|---|---|---|---|---|
| All Samples | 97/120 (81 %) |
54/122 (44 %) |
90/121 (74 %) |
94/122 (74 %) |
35/113 (31 %) |
19/113 (17%) |
| Primary | 67/81 (83 %) |
39/82 (48 %) |
68/82 (83 %) |
66/82 (80 %) |
25/77 (32 %) |
14/77 (18 %) |
| Negative | 14/81 (17%) |
43/82 (52 %) |
14/82 (17 %) |
16/82 (20 %) |
||
| Weak | 5/81 (6 %) |
10/82 (12 %) |
14/82 (17 %) |
15/82 (18 %) |
||
| Moderate/Strong | 62/81 (77 %) |
30/82 (37 %) |
54/82 (66 %) |
51/82 (62 %) |
||
| Metastatic | 30/39 (77 %) |
15/40 (38 %) |
22/39 (56 %) |
28/40 (70 %) |
10/36 (28 %) |
5/36 (14 %) |
| Negative | 9/39 (23 %) |
25/40 (62 %) |
16/39 (41 %) |
12/40 (30 %) |
||
| Weak | 2/39 (5 %) |
1/40 (3 %) |
2/39 (5 %) |
7/40 (18 %) |
||
| Moderate/Strong | 28 39 (72 %) |
14/40 (35 %) |
21/39 (54 %) |
21/40 (53 %) |