Table 5. Caco-2 DE exosomal miRNAs target pathway involvement.
Statistically pathways retrieved for each database are reported with the specific adjusted p-value between brackets.
| Caco-2 pathway involvement | Biocarta (adj. pvalue) | Reactome (adj. pvalue) | Kegg database (adj.pvalue) | GO biological process (adj. pvalue) |
|---|---|---|---|---|
| Notch signaling pathway | h_notchpathway (1.49977E-3) | Signaling by Notch (2.49195E-10) | Notch signaling pathway (2.13939E-9) | Notch signaling pathway (2.96332E-8) |
| Immunity | h_tcrPathway (7.74677E-3) | Signaling in Immune system (1.24332E-2) | T cell receptor signaling pathway (2.6041E-7) | |
| h_bcrPathway (2.1619E-2) | B cell receptor signaling pathway (2.6041E-7) | |||
| h_il2rbPathway (2.899E-2) | ||||
| Axon guidance | Axon guidance (2.02318E-7) | Axon guidance (3.26891E-8) | ||
| EGFR signaling pathway | h_fMLPpathway (1.7231E-2) | Signaling by EGFR (9.59843E-4) | ErbB signaling pathway (1.291E-7) | regulation of cell proliferation (6.82672E-10) |
| h_erkPathway (2.04915E-2) | MAPK signaling pathway (4.56095E-7) | positive regulation of cell proliferation (1.06127E-8) | ||
| h_erbB4pathway (2.1619E-2) | regulation of developmental process (9.49053E-14) | |||
| h_dspPathway (2.93048E-2) | cell morphogenesis involved in differentiation (2.44283E-7) | |||
| h_cblPathway (3.68769E-2) | regulation of cell proliferation (6.82672E-10) | |||
| Signal trasduction | h_gpcrPathway (2.04915E-2) | regulation of signal transduction (2.20524E-7) | ||
| positive regulation of small GTPase-mediated signal transduction (5.38885E-8) | ||||
| Apoptosis | h_deathPathway (2.04915E-2) | Apoptosis (1.03569E-2) | negative regulation of apoptosis (6.82672E-10) | |
| h_fasPathway (0.0221267E-2) | negative regulation of programmed cell death (7.43189E-10) | |||
| h_mef2dPathway (0.0368769E-2) | anti-apoptosis (5.58559E-7) | |||
| regulation of programmed cell death (6.12346E-7) | ||||
| Cell cycle | h_cdc42racPathway (2.49196E-2) | Cell Cycle, Mitotic (1.28553E-2) | Cell cycle (9.16981E-6) | cell cycle (1.63257E-7) |
| h_rbPathway (3.68769E-2) | ||||
| h_cdc25Pathway (2.49196E-2) | ||||
| Nerve growth factor (NGF) | Signalling by NGF (2.02318E-7) | Neurotrophin signaling pathway (3.10315E-8) | ||
| Insulin signaling pathway | Signaling by Insulin receptor (3.99996E-3) | Insulin signaling pathway (1.89788E-4) | ||
| Cell junction | Cell junction organization (8.31255E-3) | Tight junction (2.92519E-5) | ||
| Focal adhesion (9.02754E-5) |