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. 2014 Aug 21;1(8):513–521. doi: 10.18632/oncoscience.74

Figure 2. Protein patterns in radioresistant FaDu-IRR cells.

Figure 2

(A) Proteins differently expressed in parental and treatment-resistant FaDu cells were identified by two-dimensional differential gel electrophoresis (2-D DIGE) followed by MALDI-TOF/TOF mass spectrometry. (B) Identified proteins were evaluated for their common targets and activated processes in radioresistant HNSCC cells. Visual representation of molecular networks of DIGE- and software-found proteins and cell processes was performed using two versions of the software PathwayStudio 8.0 (Ariadne Genomics Inc.) [9] and PathwayStudio 10.3 (Elsevier B.V., Amsterdam, The Netherlands) based on valuable Medline citations from various investigators. Key for the represented shapes: ellipse – identified proteins; rectangles – cell processes. Green ellipses indicate DIGE-identified down-regulated proteins, red ellipses represent up-regulated proteins, orange ellipses indicate software-found proteins. Grey arrows show the relationship between cell processes and identified proteins [9].