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. 2014 Aug 6;1(8):529–539. doi: 10.18632/oncoscience.71

Figure 1. PEP005 has anti-leukaemic effects in vitro.

Figure 1

Primary AML blasts were isolated from the peripheral blood of patients diagnosed with AML. A. Isolated cells were cultured in the absence or presence of the indicated concentrations of PEP005 for 3 days. Cell viability was measured using annexin-V/PI staining. Annexin-V negative and PI negative cells were taken as the viable cell population. B. Isolated cells were cultured in medium containing SCF, GM-CSF and Flt-3 ligand, in the presence or absence of the indicated concentrations of PEP005. 7 days later, proliferation was measured using 3H-thymidine incorporation and data are expressed as counts per minute (CPM). The horizontal bar indicates the mean value. ** indicates p<0.01, *** indicates p<0.001