. Author manuscript; available in PMC: 2014 Dec 29.

Published in final edited form as: Exp Eye Res. 2013 Jul 19;115:189–198. doi: 10.1016/j.exer.2013.07.003

TABLE 4.

Prediction of miRNA-targeted genes

Gene symbol	Predicted targets among the 31 differentially expressed mRNAs (fold change ≥ 2. false discovery rate of 10%)
*Epithelial-mesenchymal transition*
MIR200A	SERPINB13, SEMA3E, SULF2
MIR200B	FN1, SERPINB13, SEMA3E, SULF2, KLHL14
MIR141	SERPINB13, SEMA3E, SULF2
*Tissue fibrosis*
MIR29B	None
*Angiogenesis*
MIR31	None
MIR451	None

The miRNA-targeted genes were predicted by the miRNA-mRNA target databases Target Scan (www.targetscan.org/). TargetScan predicts biological targets of miRNAs by searching for the presence of conserved 8mer and 7mer sites that match the seed region of each miRNA.