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. 2015 Jan;185(1):252–265. doi: 10.1016/j.ajpath.2014.09.012

Figure 1.

Figure 1

Pigment epithelium-derived factor (PEDF) is strongly expressed in the nevus cells of common melanocytic nevi (CN). A–C, G–I, and M–O: Three representative specimens of CN exhibit diffuse expression of PEDF in both junctional and intradermal nevus cells. PEDF expression is localized to the cytoplasm and nucleoli (C, I, and O). D–F, J–L, and P–R: Serial sections from the same three specimens show diffuse nuclear and cytoplasmic expression of microphthalmia-associated transcription factor (MITF). Scale bars: 50 μm (left column); 25 μm (middle column); 6 μm (right column).