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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Curr Opin Allergy Clin Immunol. 2014 Oct;14(5):381–389. doi: 10.1097/ACI.0000000000000102

Table 1.

Variant Allele Frequencies of Asthma Susceptibility Loci in Different Ancestral Populations and United States Ethnic Groups.

Gene Names ChrPos Gene ID Associated
SNP Locusa 		Alleles
Major/Minor		 Minor Allele Frequency by Racial Groupb References
CEU YRI ASW MEX CHB JPT
Interleukin-6 Receptor 1q21 IL6R rs4129267 C/T 0.35 0.07 0.15 0.52 0.39 0.36 [17]
Pyrin and HIN Domain Family Member 1 1q23 PYHIN1 rs1102000 A/G 0.00 0.35 NA NA 0 0 [18]
Interleukin-1 Receptor 2q12 IL1RL1 rs1420101 C/T 0.35 0.32 0.43 0.27 0.39 0.46 [15, 16]
Interleukin-18 Receptor 2q12 IL18R1 rs3771166 G/A 0.41 0.72 0.65 0.28 0.13 0.18 [15]
Dipeptidyl Peptidase-10 2q14 DPP10 rs1435879 A/G 0.10 0.03 0.04 0.19 0.31 0.30 [19]
GRB2-Associated Binding Protein 1 4q31 GAB1 rs1397527 G/T 0.45 0.84 0.74 NA 0.31 0.30 [20]
Ubiquitin Specific Peptidase 38 4q31 USP38 rs7686660 T/G 0.21 0.47 0.44 0.52 0.74 0.72 [20]
cAMP-Specific Phosphodiesterase 4D 5q11 PDE4D rs1588265 A/G 0.36 0.16 0.22 0.22 0.70 0.73 [21]
WD Repeat Domain 36 5q22 WDR36 rs2416257 C/T 0.14 0.14 0.10 0.06 0.07 0.04 [22]
Thymic Stromal Lymphopoietin 5q22 TSLP rs1837253 C/T 0.28 0.34 0.29 0.30 0.62 0.66 [15, 16, 19, 20]
RAD50 Homolog 5q31 RAD50 rs2244012 A/G 0.20 0.73 0.51 0.18 0.19 0.19 [23]
Interleukin-13 5q31 IL13 rs1295686 C/T 0.22 0.73 0.59 0.48 0.34 0.30 [23, 24]
α-1B-Adrenergic Receptor 5q33 ADRA1B rs10515807 G/A 0.16 0.03 NA NA 0.32 0.34 [25]
TNFAIP3 Interacting Protein 1 5q33 TNIP1 rs1422673 C/T 0.19 0.43 0.37 0.47 0.56 0.51 [24]
Psoriasis Susceptibility 1 Candidate 1 6p21 PSORS1C1 rs3094663 C/T 0.27 0.24 0.36 0.28 0.31 0.35 [16]
Human Leukocyte Antigen Complex DQB1 6p21 HLA-DQB1 rs9273349 C/T 0.42 0.48 0.47 0.23 0.39 0.44 [15, 16, 23]
Human Leukocyte Antigen Complex DRA 6p21 HLA-DRA rs2395185 G/T 0.43 0.19 0.20 0.35 0.37 0.39 [24]
Interleukin-33 9p24 IL33 rs1342326 A/C 0.17 0.35 0.32 0.15 0.00 0.00 [15, 16, 19]
GATA Binding Protein 3 10p14 GATA3 rs10508372 G/A 0.04 0.22 0.21 0.35 0.59 0.56 [20]
Ikaros Family Zinc Finger 4 12q13 IKZF4 rs1701704 T/G 0.32 0.07 0.15 0.21 0.23 0.22 [20]
SMAD Family Member 3 15q22 SMAD3 rs744910 A/G 0.45 0.68 0.67 0.54 0.58 0.56 [15]
RAR-Related Orphan Receptor A 15q22 RORA rs11071559 C/T 0.15 0.56 0.43 0.11 0.14 0.23 [15]
ORM1-Like 3 17q12 ORMDL3 rs7216389 C/T 0.49 0.88 0.70 0.60 0.66 0.72 [15, 18, 19, 21, 26–29]
Gasderminlike B 17q12 GSDMB rs2305480 G/A 0.47 0.05 0.25 0.40 0.33 0.28 [15, 16, 24, 29]
Ikaros Family Zinc Finger 3 17q12 IKZF3 rs907092 G/A 0.49 0.07 0.28 0.39 0.33 0.34 [16]
Prion-Related Protein 20p12 PRNP rs6052761 T/C 0.10 0.35 0.39 0.17 0 0.03 [25]
Interleukin-2 Receptor, β Subunit 22q12 IL2RB rs2284033 G/A 0.42 0.39 0.45 0.32 0.65 0.58 [15]
a

Asthma susceptibility loci selected among the first identified by genome-wide association studies or admixture mapping and denoted by reference sequence number (rs) [15–29].

b

Minor or less common, variant allele frequencies are based on data from the International HapMap Project Genome Browser release 28 accessed on June 23, 2014 (http://hapmap.ncbi.nlm.nih.gov/cgi-perl/gbrowse/hapmap28_B36/).

Abbreviations from each group are as follows: CEU=Utah residents with ancestry from northern and western Europe; YRI=Individuals from Yoruba in Ibadan, Nigeria; ASW=African Americans from the southwest United States; MEX=Mexican Americans from Los Angeles, CA; CHB=Han Chinese from Beijing, China; JPT=Japanese from Tokyo, Japan.