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. Author manuscript; available in PMC: 2014 Dec 29.
Published in final edited form as: Melanoma Res. 2014 Aug;24(4):342–348. doi: 10.1097/CMR.0000000000000062

Table 1.

Nab-paclitaxel dose-escalation schedule

Dose level Nab-paclitaxel
(i.v.; day 1)
(mg/m2)		 Temozolomide
(PO; days 1–3) (mg/m2)		 Cisplatin (i.v.; days 1–4)
(mg/m2)		 IL-2 (CI; days 1–4)
(106) (IU/m2)		 Nab-paclitaxel
(i.v.; day 5) (mg/m2)		 IFN-α2b (SQ; days 1–5)
(106) (IU/m2)
−1 80 250 20 9 70 5
0 100 250 20 9 70 5
1 120 250 20 9 70 5
2 140 250 20 9 70 5

CI, continuous intravenous infusion; IFN-α2b, interferon-α2b; IL-2, interleukin-2; i.v., intravenous; PO, per overall survival; SQ, subcutaneous injection.