Table 4.
Treatment-related toxicity
| Toxicity | Total instances (% out of 46 cycles) [n (%)] |
Patients with toxicity grade 3/4 |
|---|---|---|
| Neutropenia | 20 (43) | 12 |
| Thrombocytopenia | 20 (43) | 4 |
| Anemia | 19 (41) | 2 |
| Lymphopenia | 3 (7) | 2 |
| Diarrhea | 36 (78) | 3 |
| Fatigue | 35 (76) | 2 |
| Nausea | 30 (65) | 0 |
| Skin rash | 25 (54) | 1 |
| Headache | 21 (46) | 0 |
| Hypotension | 20 (43) | 0 |
| Pruritus | 20 (43) | 0 |
| Constipation | 16 (35) | 0 |
| Taste alteration | 16 (35) | 0 |
| Neuropathy | 14 (30) | 1 |
| Alopecia | 14 (30) | 0 |
| Chills | 13 (28) | 0 |
| Vomiting | 13 (28) | 0 |
| Tinnitus | 8 (17) | 1 |
| Hypomagnesemia | 7 (15) | 0 |
| Anxiety | 7 (15) | 0 |
| Hearing loss | 4 (9) | 0 |
| Infection | 4 (9) | 3 |
| Alanine aminotransferase elevation |
4 (9) | 2 |