Table 3. Regression coefficients (β) and P values for association of non-genetic covariates with continuous outcome variables at month 12 and 24.
| Age | Sex | Smoking | Baseline BCVA | Baseline CSMT | Baseline CNV lesion size | Lesion type | AMD status of fellow eye | ||
|---|---|---|---|---|---|---|---|---|---|
| BCVA change from baseline |
at month 12 |
-0.244 ± 0.124 |
0.165 ± 2.224 |
3.846 ± 2.342 |
-0.395 ± 0.065 |
-0.004 ±0.01 |
-0.433 ± 0.210 |
0.477 ±2.313 |
2.056 ±1.721 |
| (P = 0.035) |
(P = 0.931) |
(P = 0.089) |
(P < 0.001) |
(P = 0.709) |
(P = 0.046) |
(P = 0.830) |
(P = 0.452) |
||
| at month 24 |
-0.461 ± 0.138 |
0.661 ± 2.683 |
2.796 ± 2.717 |
-0.434 ± 0.054 |
0.002 ± 0.011 |
-0.726 ± 0.267 |
-0.561± 2.791 |
2.627 ±1.071 |
|
| (P = 0.001) |
(P = 0.805) |
(P = 0.304) |
(P < 0.001) |
(P = 0.836) |
(P = 0.007) |
(P = 0.841) |
(P = 0.605) |
||
| CSMT change from baseline |
at month 12 |
1.341 ± 0.452 |
-3.947 ± 9.116 |
-4.692 ± 9.230 |
0.163 ± 0.192 |
-0.728 ± 0.139 |
1.324 ± 0.895 |
16.833± 9.367 |
-3.112 ±5.212 |
| (P = 0.004) |
(P = 0.653) |
(P = 0.618) |
(P = 0.376) |
(P < 0.001) |
(P = 0.134) |
(P = 0.075) |
(P = 0.385) |
||
| at month 24 | 1.452 ± 0.545 |
-34.408 ± 10.623 |
-30.274 ± 10.758 |
-0.312 ± 0.214 |
-0.796 ± 0.045 |
2.176 ± 1.057 |
-7.058± 11.049 |
-4.772 ±3.832 |
|
| (P = 0.008) | (P = 0.101) | (P = 0.105) | (P = 0.146) | (P < 0.001) | (P = 0.140) | (P = 0.523) | (P = 0.152) |
BCVA = Best-corrected visual Acuity; CSMT = Central subfield macular thickness; CNV = Choroidal neovascularization; AMD = Age-related macular degeneration