Table 1. Characteristics of candidate genetic markers.
| Chr | Gene | Location | dbSNP ID | Major/Minor Allele | MAF | Genotyping Method | HWE P - value | Genotyping rate |
|---|---|---|---|---|---|---|---|---|
| 1 |
CFH |
I62V |
rs800292 |
G/A |
0.281 |
SNaPshot |
0.503 |
100% |
| 1 |
CFH |
Y402H |
rs1061170 |
T/C |
0.097 |
SNaPshot |
1 |
99.0% |
| 1 |
CFH |
IVS14–543A/G |
rs1410996 |
G/A |
0.314 |
Taqman |
0.213 |
99.8% |
| 6 |
CFI |
64060C/T |
rs10033900 |
T/C |
0.302 |
Taqman |
0.633 |
99.8% |
| 6 |
C2 |
E318D |
rs9332739 |
G/C |
0.014 |
Taqman |
0.098 |
100% |
| 6 |
CFB |
R32Q |
rs641153 |
G/A |
0.063 |
SNaPshot |
1 |
99.5% |
| 6 |
SKIV2L |
3493G/A |
rs429608 |
G/A |
0.071 |
Taqman |
0.144 |
99.5% |
| 6 |
VEGFA |
C-2578A |
rs699947 |
C/A |
0.298 |
SNaPshot |
0.087 |
99.5% |
| 6 |
VEGFA |
C936T |
rs3025039 |
C/T |
0.234 |
Taqman |
0.401 |
100% |
| 10 |
ARMS2 |
A69S |
rs10490924 |
T/G |
0.313 |
Taqman |
0.043 |
99.8% |
| 10 |
HTRA1 |
−625A/G |
rs11200638 |
A/G |
0.315 |
Taqman |
0.008 |
100% |
| 12 |
SCARB1 |
A350A |
rs5888 |
C/T |
0.262 |
Taqman |
0.425 |
99.8% |
| 17 |
PEDF |
Met72Thr |
rs1136287 |
C/T |
0.489 |
Taqman |
1 |
99.5% |
| 19 |
C3 |
R80G |
rs2230199* |
C/G |
0 |
Taqman |
1 |
99.7% |
| 19 |
APOE |
Cys112Arg |
rs429358 |
T/C |
0.095 |
Taqman |
0.336 |
98.7% |
| 19 |
APOE |
Arg158Cys |
rs7412 |
C/T |
0.063 |
Taqman |
1 |
98.6% |
| 22 | SYN3/TIMP3 | IVS5–91789G/T | rs9621532 | T/G | 0.027 | SNaPshot | 0.508 | 99.8% |
SNP=Single nucleotide polymorphism (dbSNP ID); MAF=Minor allele frequency; HWE=Hardy–Weinberg Equilibrium; IVS=Intervening sequence *: Excluded from analysis because all patients showed CC genotype