. 2014 May 9;165(4):373–380. doi: 10.1002/ajmg.b.32241

I.

Replicated Tests of Association for GWAS TACR1 SNPs in the UCL1 and UCL2 Bipolar Affective Disorder Cases, Comorbid Bipolar Alcohol Dependence Subsample, and Alcohol Dependence Syndrome Cases Compared With Both Screened and Unscreened Controls

		rs3771833^a							rs3771829^a
	Sample size	MAF^a	Screened controls^b		Unscreened controls^c		Combined controls		MAF^d	Screened controls^a		Unscreened controls^c		Combined controls
	Sample size	MAF^a	P-value^e	OR (95 % CI)^f	P-value^e	OR (95 % CI)^f	P-value^e	OR (95 % CI)^f	MAF^d	P-value^e	OR (95% CI)^f	P-value^e	OR (95% CI)^f	P-value^e	OR (95% CI)^f
BPAD^g	1099	0.118	0.0043	1.43 (1.12–1.83)	0.511	1.09 (0.84–1.42)	0.0189	1.27 (1.04–1.56)	0.092	0.0018	1.57 (1.18–2.08)	0.657	0.94 (0.71–1.24)	0.057	1.24 (0.99–1.56)
BPALC^h	143	0.120	0.0759	1.45 (0.96–2.20)	0.608	1.12 (0.73–1.71)	0.572	1.17 (0.74–1.70)	0.108	0.0051	1.87 (1.20–2.92)	0.615	1.12 (0.72–1.75)	0.057	1.49 (0.99–2.24)
ADSⁱ	997	0.107	0.0537	1.28 (1.00–1.65)	0.878	0.98 (0.75–1.28)	0.216	1.14 (0.93–1.41)	0.092	0.0022	1.56 (1.17–2.09)	0.649	0.94 (0.70–1.25)	0.066	1.24 (0.99–1.56)
BPAD + ADS	2,096	0.113	0.0087	1.36 (1.08–1.71)	0.769	1.04 (0.81–1.33)	0.150	1.16 (0.95–1.42)	0.092	0.0009	1.57 (1.20–2.04)	0.628	0.94 (0.72–1.22)	0.034	1.27 (1.02–1.59)
Screened controls	672	0.086	—	—	0.086	1.31 (0.96–1.79)	—	—	0.061	—	—	0.003	1.67 (1.19–2.36)	—	—
Unscreened controls	384	0.109	—	—	—	—	—	—	0.098	—	—	—	—	—	—

dbSNPrsID, Reference single nucleotide polymorphism (rs) ID given. Position on chromosome 2; hg19 Build NCBI37, May 2009, associated gene, NM_001058: rs3771833 (T > C) 75,366,937; rs3771829 (G > C) 75,364,145.

Screened control population has been screened for a history of mental illness and drinking behavior.

Unscreened control population has not been screened for a history of mental illness and drinking behavior.

MAF, minor allele frequency.

P-value.

OR(95 % CI), odds ratio with 95% confidence intervals in parentheses.

BPAD bipolar affective disorder University College London sample numbers 1 and 2 (UCL1 & UCL2) combined.

BPALC, subsample of UCL1 BPAD with comorbid alcohol dependence syndrome.

ⁱ

ADS, alcohol dependence syndrome University College London sample.