Table 2.
No. of patients* |
5-year OS (%) |
p Value | 5-year DPFS (%) |
p Value | ||
---|---|---|---|---|---|---|
Race | ||||||
White | 119 | 30 | 0.05 | 20 | <.001 | |
Black | 32 | 17 | 0 | |||
Other | 21 | 38 | 27 | |||
ECOG Performance Status | ||||||
0-1 | 126 | 31 | 0.01 | 18 | 0.002 | |
>1 | 29 | 11 | 5 | |||
Menopausal status | ||||||
Post | 100 | 34 | 0.44 | 21 | 0.79 | |
Pre | 69 | 27 | 14 | |||
Hormone receptor | ||||||
Pos | 89 | 31 | 0.12 | 15 | 0.81 | |
Neg | 77 | 25 | 18 | |||
HER2 receptor | ||||||
Pos | 45 | 44 | 0.002 | 25 | <.001 | |
Neg | 117 | 20 | 11 | |||
Grade | ||||||
1 | 3 | 67 | 0.73 | 33 | 0.47 | |
2 | 38 | 24 | 15 | |||
3 | 120 | 28 | 17 | |||
LVSI | ||||||
Yes | 78 | 27 | <.001 | 16 | <.001 | |
No | 39 | 52 | 40 | |||
Unknown | 55 | |||||
Histology | ||||||
Ductal | 136 | 30 | 0.92 | 18 | 0.88 | |
Lobular | 13 | 42 | 19 | |||
Mixed | 14 | 19 | 9 | |||
Systemic therapy | ||||||
Chemo only | 117 | 28 | 0.63 | 17 | 0.42 | |
Chemo+endocrine | 55 | 29 | 8 | |||
Response to systemic therapy | ||||||
Non-responders | 69 | 13 | <.0001 | 8 | <.0001 | |
Responders | 98 | 41 | 24 | |||
Locoregional therapy | ||||||
None | 75 | 9 | <.0001 | 0 | <.0001 | |
Radiotherapy alone | 18 | 14 | 15 | |||
Surgery alone | 11 | 25 | 18 | |||
Surgery+radiotherapy | 68 | 50 | 32 | |||
Surgery | ||||||
Yes | 79 | 47 | <.0001 | 30 | <.0001 | |
No | 93 | 10 | 3 | |||
Surgical intent | ||||||
Curative | 47 | 49 | 0.66 | 35 | 0.56 | |
Local control | 32 | 44 | 24 | |||
Margin status | ||||||
Negative | 60 | 48 | 0.92 | 33 | 0.38 | |
Positive | 7 | 47 | 42 | |||
Close | 8 | 40 | 25 | |||
pCR | ||||||
Yes | 12 | 60 | <.001 | 61 | <.001 | |
No | 67 | 26 | 13 | |||
# distant disease sites | ||||||
1 | 94 | 34 | 0.05 | 24 | <.001 | |
>1 | 78 | 18 | 6 |
Patients with unknown data were excluded, thus totals may vary
Abbreviations: OS, overall survival; DPFS, distant progression-free survival; ECOG, Eastern Cooperative Oncology Group; LVSI, lymphovascular space invasion; pCR pathologic complete response