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Expression of cyclooxygenase 2 (COX2) protein by adult rat lungs stimulated in vitro with normal (HbAA) or sickle cell (HbSS) peptides. Adult rat lungs were prepared for studies as described in “Methods.” Proteins were prepared, and COX2 expression was measured by Western blotting. HbSS peptide increased expression of COX2 protein. Data are means + SEM. An asterisk indicates significant (P < 0.05) difference from effects of both Krebs buffer control and HbAA peptide.
