Figure 12.

Amount of 6-keto-PGF_1α measured from lung explants cultured with normal (HbAA) or sickle cell (HbSS) peptides. HbSS peptide stimulated release of 6-keto-PGF_1α at a level comparable to effect of A23187 and higher than the effect of HbAA peptide or Krebs buffer control. Data are means + SEM. ND: none detected. An asterisk indicates release significantly (P < 0.05) greater than that for Krebs control; a pound sign (#) indicates release significantly (P < 0.05) greater than that for both HbAA peptide and Krebs control.