Figure 13.

Amount of leukotrienes measured from lung explants cultured with normal (HbAA) or sickle cell (HbSS) peptides. HbSS peptide stimulated release of leukotrienes at a level comparable to effect of A23187 and higher than the effect of HbAA peptide or Krebs buffer control. Data are means + SEM. A single asterisk indicates release significantly (P < 0.05) greater than that for Krebs control; double asterisks indicate release significantly (P < 0.05) different from that under all other treatments; a pound sign (#) indicates release significantly (P < 0.05) greater than that for both HbAA peptide and Krebs control.