Figure 9.

Expression of inflammatory protein platelet-activating factor receptor (PAFR) by rat lung explants stimulated in vitro with normal (HbAA) or sickle cell (HbSS) peptides. Adult rat lungs were prepared for studies as described in “Methods.” Proteins were prepared, and PAFR was measured by Western blotting. HbSS peptide increased expression of PAFR. Data are means + SEM. An asterisk indicates significant (P < 0.05) difference from Krebs buffer control; a pound sign (#) indicates significant (P < 0.05) difference from effects of both Krebs buffer control and HbAA peptide.