Table 4.

Percent change in prostaglandin E₂ (PGE₂) levels, relative to baseline levels, measured in effluents of isolated rat lung perfused with GPBS, HbAA-RBCs, and HbSS-RBCs and the perfusates combined with autologous platelet-rich plasma (PRP)

Perfusate	15 min	+PRP, 0 min	+PRP, 15 min	+PRP, 30 min
GPBS	NC	NC	NC	NC
HbAA RBCs	ND	ND	ND	ND
HbSS RBCs	160	314	240	349

^NoteMeasurements were taken after 15 minutes of perfusion with perfusate alone and 3 times after addition of PRP: immediately (0 min), 15 minutes later (15 min), and after 15 more minutes, during which the perfusion rate was twice the initial rate (30 min); see “Experimental design.” GBPS: phosphate-buffered saline containing 131 mM NaCl, 5.1 mM Na₂HPO₄, 1.5 mM KH₂PO₄, 1% bovine serum albumin, and 8.3 mM glucose; HbAA: hemoglobin AA; HbSS: hemoglobin SS; RBCs: red blood cells; NC: no change; ND: none detected in the assay.