Table 1.
Animal characteristics at euthanasia
| Variable | Sham surgery (n = 8) | PTB (n = 8) | MCT (n = 7) |
|---|---|---|---|
| Liver weight/animal weight, % | 3.3 ± 0.03 | 3.0 ± 0.05** | 3.4 ± 0.06## |
| Spleen weight/animal weight, % | 0.23 ± 0.14 | 0.24 ± 0.14 | 0.20 ± 0.10# |
| Lung weight/animal weight, % | 0.46 ± 0.02 | 0.47 ± 0.01 | 1.07 ± 0.07**,# |
| RV weight/tibia length, g cm−1 | 0.004 ± 0.0003 | 0.011 ± 0.0005** | 0.008 ± 0.0008**,## |
| Fibrosis fraction, % | 0.29 ± 0.031 | 0.79 ± 0.089** | 0.31 ± 0.039### |
| ANP, pg mL−1 | 561 ± 94 | 708.± 101 | 1,515 ± 218*,## |
| Animal weight, g | 311 ± 4 | 275 ± 6** | 213 ± 8**,### |
Note
Data are mean ± SEM. PTB: pulmonary trunk banding; MCT: monocrotaline; RV: right ventricle; ANP: atrial natriuretic peptide.
*
P < 0.05 versus sham.
**
P < 0.001 versus sham.
#
P < 0.05 versus PTB.
##
P < 0.01 versus PTB.
###
P < 0.001 versus PTB.