Table 2.
Baseline hemodynamics
| Variable | Sham surgery (n = 8) | PTB (n = 8) | MCT (n = 7) |
|---|---|---|---|
| Mean arterial pressure, mmHg | 92 ± 4 | 85 ± 4 | 68 ± 7**,# |
| RV end systolic pressure, mmHg | 27 ± 2 | 104 ± 6*** | 56 ± 4***,### |
| RV dP/dtmax, mmHg s−1 | 2,038 ± 194 | 5,261 ± 474*** | 2,784 ± 276*,### |
| RV dP/dtmin, mmHg s−1 | −1,932 ± 191 | −4,266 ± 281*** | −2,321 ± 179### |
| TAPSE, cm | 0.19 ± 0.006 | 0.12 ± 0.005*** | 0.11 ± 0.003*** |
| Tricuspid regurgitation, % | 25 | 100** | 100** |
| PVR, dyn × s × cm−5 | 19,400 ± 978 | 135,800 ± 6,982*** | 138,900 ± 20,900*** |
| Heart rate, bpm | 406 ± 14 | 339 ± 20* | 313 ± 21** |
| RV stroke volume, mL | 0.28 ± 0.01 | 0.18 ± 0.008** | 0.12 ± 0.02**,## |
| RV cardiac output, mL min−1 | 114 ± 7 | 62 ± 3*** | 38 ± 8***,# |
| RV end systolic volume, μL | 76 ± 10 | 228 ± 20*** | 212 ± 15*** |
| RV end diastolic volume, μL | 337 ± 18 | 425 ± 22** | 342 ± 9## |
| RV ejection fraction, % | 78 ± 2 | 47 ± 3*** | 39 ± 3*** |
Note
Data are mean ± SEM. PTB: pulmonary trunk banding; MCT: monocrotaline; RV: right ventricle; TAPSE: tricuspid annular plane systolic excursion; PVR: pulmonary vascular resistance (estimated as RV end systolic pressure divided by RV cardiac output); bpm: beats per minute.
*
P < 0.05 versus sham.
**
P < 0.01 versus sham.
***
P < 0.001 versus sham.
#
P < 0.05 versus PTB.
##
P < 0.01 versus PTB.
###
P < 0.001 versus PTB.