Table 2.
Parameters of cardiovascular function after drug-free vehicle infusion and dose-response data
| Parameter | Baseline | Vehicle | Iloprost 10 μg/kg | Iloprost 20 μg/kg |
|---|---|---|---|---|
| Heart rate, bpm | 262 ± 18 | 248 ± 22 | 313 ± 17 | 384 ± 10 |
| RVSP, mmHg | 33.33 ± 3.33 | 31.67 ± 0.88 | 35.33 ± 2.19 | 42 ± 2.52 |
| RV contractility index, 1/sa | 154.0 ± 13.5 | 140.3 ± 3.76 | 181.0 ± 21.5 | 214.7 ± 25.4 |
| Cardiac output, μL/min | 42,965 ± 5,770* | 39,753 ± 641* | 69,195 ± 10,573* | 72,015 ± 6,515* |
| Stroke volume, μL | 165.3 ± 23.1 | 162.7 ± 11.1 | 218.7 ± 25.0 | 187.0 ± 13.1 |
| ESPVR slope, mmHg/mL | 0.3 ± 0.06 | 0.28 ± 0.07 | 0.43 ± 0.08 | 0.46 ± 0.08 |
| Ea, mmHg/mL | 0.16 ± 0.01 | 0.18 ± 0.02 | 0.20 ± 0.05 | 0.18 ± 0.04 |
| ESPVR slope/Ea | 1.87 ± 0.32 | 1.58 ± 0.42 | 2.25 ± 0.32 | 2.63 ± 0.39 |
Note
Data are reported as means ± SEM. N = 3 rats. Ea: arterial elastance; ESPVR: end-systolic pressure-volume relationship; RV: right ventricular; RVSP: right ventricular systolic pressure.
a
Maximum dP/dt normalized for instantaneous pressure.
*
P < .05. by ANOVA.