Figure 8.

Circulating leptin, adiponectin, and inflammatory cytokine levels in Zucker (Zuck) lean/fatty and diet-resistant/diet-induced obesity (DR/DIO) rat models. Eight-week-old male Zucker lean (white bars) and fatty (hatched bars) rats were fed standard chow ad lib. for 5 months. Eight-week-old male DR and DIO rats were fed either a low-fat (white bars) or a high-fat (black bars) diet ad lib. for 5 months. Cytokine levels were measured in blood plasma by multiplex bead assay. Values are averages from 3 experiments with 6 animals per group. IL: interleukin; MCP-1: macrophage chemoattractant protein-1; TNF-a: tumor necrosis factor α; tPAI-1: tissue plasminogen activator inhibitor-1.